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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tyrem2Ove
endonuclease-mediated mutation 2, Paul Overbeek
MGI:5817581
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		a/a
Tyrem2Ove/Tyrem2Ove 		involves: C57BL/6 * FVB MGI:5817582
cx2
 		a/a
Tyrc/Tyrem2Ove 		involves: C57BL/6 * FVB MGI:5819213


Genotype
MGI:5817582
cx1
Allelic
Composition		 a/a
Tyrem2Ove/Tyrem2Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (166 available); any a mutation (468 available)
Tyrem2Ove mutation (1 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal tail pigmentation ( J:94077 )
• the tails of these mice are lightly pigmented

vision/eye
abnormal eye pigmentation ( J:94077 )
• these mice exhibit altered ocular pigmentation compared to wild-type mice

integument
diluted coat color ( J:94077 )
• mice homozygous for this tyrosinase promoter mutation on a nonagouti background appear light gray
abnormal tail pigmentation ( J:94077 )
• the tails of these mice are lightly pigmented

pigmentation
diluted coat color ( J:94077 )
• mice homozygous for this tyrosinase promoter mutation on a nonagouti background appear light gray
abnormal tail pigmentation ( J:94077 )
• the tails of these mice are lightly pigmented
abnormal eye pigmentation ( J:94077 )
• these mice exhibit altered ocular pigmentation compared to wild-type mice




Genotype
MGI:5819213
cx2
Allelic
Composition		 a/a
Tyrc/Tyrem2Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (166 available); any a mutation (468 available)
Tyrc mutation (79 available); any Tyr mutation (382 available)
Tyrem2Ove mutation (1 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• on a nonagouti background, the fur of these compound Tyr heterozygotes appears lighter gray than that of mice homozygous for Tyrem2Ove

pigmentation
diluted coat color ( J:94077 )
• on a nonagouti background, the fur of these compound Tyr heterozygotes appears lighter gray than that of mice homozygous for Tyrem2Ove
decreased eye pigmentation ( J:94077 )
• these mice exhibit lighter ocular pigmentation than Tyrem2Ove homozygotes

vision/eye
decreased eye pigmentation ( J:94077 )
• these mice exhibit lighter ocular pigmentation than Tyrem2Ove homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory