Phenotypes associated with this allele

• Allele Symbol: Grin2a^tm1.1Jpleo
• Allele Name: targeted mutation 1.1, John P Leonard
• Allele ID: MGI:5811328
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2a^tm1.1Jpleo/Grin2a^tm1.1Jpleo	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5811660

Genotype
MGI:5811660

hm1

• Allelic Composition: Grin2a^tm1.1Jpleo/Grin2a^tm1.1Jpleo
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:235504 )

• alternation rate is decreased in Y maze and delayed T arm maze as compared to controls

• however, there is no significant difference in general activity levels

abnormal spatial working memory ( J:235504 )

• alternation rate is decreased in Y maze and delayed T arm maze as compared to controls

• however, there is no significant difference in general activity levels

decreased anxiety-related response ( J:235504 )

• mice exhibit reduced anxiety levels as measured by open field, light/dark box, and elevated plus maze

• increased time in center of open field

• more time in the lit compartment of the light-dark box

• increased time in open arms of elevated plus maze

nervous system

nervous system phenotype ( J:235504 )

N • measurement of brain electrophysiology, including LTP, indicated no significant genotype differences