Phenotypes associated with this allele

• Allele Symbol: Ddi2^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5810736
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddi2^tm1b(EUCOMM)Hmgu/Ddi2^tm1b(EUCOMM)Hmgu	C57BL/6NCrl-Ddi2^tm1b(EUCOMM)Hmgu/Ph	MGI:8226378
hm2	Ddi2^tm1b(EUCOMM)Hmgu/Ddi2^tm1b(EUCOMM)Hmgu	C57BL/6N-Ddi2^tm1b(EUCOMM)Hmgu/Ccpcz	MGI:6408333
ht3	Ddi2^tm1b(EUCOMM)Hmgu/Ddi2^+	C57BL/6NCrl-Ddi2^tm1b(EUCOMM)Hmgu/Ph	MGI:8226377
ht4	Ddi2^tm1b(EUCOMM)Hmgu/Ddi2^+	C57BL/6N-Ddi2^tm1b(EUCOMM)Hmgu/Ccpcz	MGI:6408332

Genotype
MGI:8226378

hm1

• Allelic Composition: Ddi2^{tm1b(EUCOMM)Hmgu}/Ddi2^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6NCrl-Ddi2^{tm1b(EUCOMM)Hmgu}/Ph
• Cell Lines: HEPD0660_5_E02

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality prior to heart atrial septation, complete penetrance ( J:354587 )

• homozygous embryos die between E11.5 and E14.5, with only one severely developmentally retarded embryo surviving to E14.5; no live embryos are recovered at E15.5

embryo

embryonic growth retardation ( J:354587 )

• homozygous embryos show severe growth retardation at E11.5 but not at E10.5

growth/size/body

embryonic growth retardation ( J:354587 )

• homozygous embryos show severe growth retardation at E11.5 but not at E10.5

Genotype
MGI:6408333

hm2

• Allelic Composition: Ddi2^{tm1b(EUCOMM)Hmgu}/Ddi2^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Ddi2^{tm1b(EUCOMM)Hmgu}/Ccpcz
• Cell Lines: HEPD0660_5_E02

Data Sources

IMPC Data for Ddi2

mortality/aging

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - CCP-IMG

preweaning lethality, complete penetrance ( J:211773 )

IMPC - CCP-IMG

Genotype
MGI:8226377

ht3

• Allelic Composition: Ddi2^{tm1b(EUCOMM)Hmgu}/Ddi2⁺
• Genetic Background: C57BL/6NCrl-Ddi2^{tm1b(EUCOMM)Hmgu}/Ph
• Cell Lines: HEPD0660_5_E02

normal phenotype

no abnormal phenotype detected ( J:354587 )

• adult heterozygous mice are viable and fertile and do not exhibit any clear distinct phenotypes at 9-16 weeks of age

Genotype
MGI:6408332

ht4

• Allelic Composition: Ddi2^{tm1b(EUCOMM)Hmgu}/Ddi2⁺
• Genetic Background: C57BL/6N-Ddi2^{tm1b(EUCOMM)Hmgu}/Ccpcz
• Cell Lines: HEPD0660_5_E02

Data Sources

IMPC Data for Ddi2

homeostasis/metabolism

impaired glucose tolerance ( J:211773 )

IMPC - CCP-IMG

renal/urinary system

abnormal urinary bladder morphology ( J:211773 )

♂

IMPC - CCP-IMG

respiratory system

increased airway resistance ( J:211773 )

♀

IMPC - CCP-IMG

skeleton

abnormal spine curvature ( J:211773 )

IMPC - CCP-IMG