Analysis Tools
hematopoietic system
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• mice develop severe adult-onset anemia (normochromic/normocytic) due to the failure of the switch of Epo production from liver to kidney
• anemia is slightly more severe in males than females and in aged mice than in young mice
• however, embryonic erythropoiesis is normal. morphology, size and hemoglobin content of erythrocytes in peripheral blood are normal, and white blood cell and platelet counts are within normal range
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• decrease of proerythroblast and basophilic erythroblast numbers in the bone marrow
• early erythroblasts are decreased in the spleen
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• mice show decreased hematocrit after 2 weeks of age
• treatment with an Epo-neutralizing antibody further decreases hematocrit
• treatment with a recombinant human EPO restores the hematocrit to normal levels with an increase in reticulocytes, indicating stress erythropoiesis
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• total splenic cells are reduced
• however, no changes in splenic architecture are seen and the size and weight of spleen remains normal
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cardiovascular system
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• cardiomegaly
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immune system
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• total splenic cells are reduced
• however, no changes in splenic architecture are seen and the size and weight of spleen remains normal
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limbs/digits/tail
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• distal femur is pale
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skeleton
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• distal femur is pale
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growth/size/body
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• cardiomegaly
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