Tg(Epo*)458Mym
Transgene Detail

Summary

• Symbol: Tg(Epo*)458Mym
• Name: transgene insertion 458, Masayuki Yamamoto
• MGI ID: MGI:5807393
• Synonyms: Tg458
• Transgene: Tg(Epo*)458Mym Location: unknown
• Alliance: Tg(Epo*)458Mym page

The snout and paws of Rr104^tm1.2Mym/Rr104^tm1.2Mym Tg(Epo*)458Mym/0 (ISAM) mice are whiter than those of controls

Show the 3 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Epo*)458Mym expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Epo (MGI:95407)	0.3-kb deletion in exon V resulting in liver-specific expression

• Mutation details: The transgene spans from 3.3-kb upstream to 4.5-kb downstream from the transcriptional start site, including the liver-specific enhancer EpoE-3 with a 0.3-kb deletion in exon V. Eleven lines were established. (J:231255)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Chronic Anemia J: 231255.

References

• Original: J:231255 Yamazaki S, et al., A mouse model of adult-onset anaemia due to erythropoietin deficiency. Nat Commun. 2013;4:1950
• All: 4 reference(s)