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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ddr2tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5806885
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ddr2tm1c(EUCOMM)Wtsi/Ddr2tm1c(EUCOMM)Wtsi
Tg(KRT14-cre)1Amc/0
Tg(MMTV-PyVT)634Mul/0 		involves: C57BL/6 * C57BL/6N * CBA * FVB/N MGI:5825268
cn2
 		Ddr2tm1c(EUCOMM)Wtsi/Ddr2tm1c(EUCOMM)Wtsi
Tg(MMTV-cre)#Mam/0
Tg(MMTV-PyVT)634Mul/0 		involves: C57BL/6N * FVB * FVB/N MGI:5825266


Genotype
MGI:5825268
cn1
Allelic
Composition		 Ddr2tm1c(EUCOMM)Wtsi/Ddr2tm1c(EUCOMM)Wtsi
Tg(KRT14-cre)1Amc/0
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddr2tm1c(EUCOMM)Wtsi mutation (1 available); any Ddr2 mutation (60 available)
Tg(KRT14-cre)1Amc mutation (2 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:236031 )
• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice and similar levels of fibrillar collagen in tumors
decreased metastatic potential ( J:236031 )
• mice show a reduction in the number of lung metastasis compared to single Tg(MMTV-PyVT)634Mul/0 mice
• in collagen I gels, a reduction in the number of invasive tumor organoids is seen
• however, in matrigel, tumor organoids show similar organoid budding and branching as single Tg(MMTV-PyVT)634Mul tumor organoids

integument
increased mammary gland tumor incidence ( J:236031 )
• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice and similar levels of fibrillar collagen in tumors

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:236031 )
• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice and similar levels of fibrillar collagen in tumors




Genotype
MGI:5825266
cn2
Allelic
Composition		 Ddr2tm1c(EUCOMM)Wtsi/Ddr2tm1c(EUCOMM)Wtsi
Tg(MMTV-cre)#Mam/0
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: C57BL/6N * FVB * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddr2tm1c(EUCOMM)Wtsi mutation (1 available); any Ddr2 mutation (60 available)
Tg(MMTV-cre)#Mam mutation (0 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:236031 )
• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice, no differences in the number of lung metastases, and similar levels of fibrillar collagen in tumors

integument
increased mammary gland tumor incidence ( J:236031 )
• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice, no differences in the number of lung metastases, and similar levels of fibrillar collagen in tumors

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:236031 )
• mice show a similar primary mammary gland tumor growth and tumor burden as single Tg(MMTV-PyVT)634Mul/0 mice, no differences in the number of lung metastases, and similar levels of fibrillar collagen in tumors




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory