Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• mice with 4 or 5 copies of the transgene die by P4
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nervous system
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• 100% of mice with 4 or 5 copies of the transgene show defects of the nerve plexus, namely hypoganglionosis in the distal part of the large intestine
• hypoganglionosis expands over the entire large intestine in mice with 5 copies of the transgene
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• terminal differentiation of oligodendrocyte lineage cells in the developing spinal cord and brain is delayed in postnatal mice with 5 copies of the transgene
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digestive/alimentary system
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• inflation of the large intestine is seen in dead mice with 4 or 5 copies of the transgene
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• a small proportion of mice with 3 copies of the transgene die around weaning
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nervous system
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• 4% of mice with 2 copies and 14% of mice with 3 copies of the transgene exhibit defects of the nerve plexus, namely hypoganglionosis in the distal part of the large intestine
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• mice with 3 copies of the transgene show less refined Remak bundles at 6 weeks of age
• some Remak bundles are enlarged and the space between axons is occasionally narrower in mice with 3 copies of the transgene
• the median number of axons in a Remak bundle is larger in mice with 3 copies of the transgene, indicating that Remak bundles contain more axons per bundle
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• mice with 3 copies of the transgene show less refined compact myelin sheaths in the sciatic nerve at 6 weeks of age
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• persistence of a thinner myelin in the sciatic nerve of mice with 3 copies of the transgene
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pigmentation
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• 58% of mice with 2 copies and 81% with 3 copies of the transgene exhibit hypopigmentation of hair color in the forelock and the trunk; this is not seen in mice with one transgene copy
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behavior/neurological
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• 73% of mice with 2 copies and 35% mice with 3 copies of the transgene exhibit rotating behavior
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digestive/alimentary system
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• inflation of the large intestine is seen in dead mice with 3 copies of the transgene
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hearing/vestibular/ear
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• auditory threshold is higher in mice with 2 or 3 copies of the transgene, indicating sensory deafness
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• mice with 2 or 3 copies of the transgene exhibit sensory deafness
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