Phenotypes associated with this allele

• Allele Symbol: Rel^M1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5806335
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rel^M1Btlr/Rel^M1Btlr	C57BL/6J-Rel^M1Btlr	MGI:5807165
ht2	Rel^M1Btlr/Rel^+	C57BL/6J-Rel^M1Btlr	MGI:5807166

Genotype
MGI:5807165

hm1

• Allelic Composition: Rel^M1Btlr/Rel^M1Btlr
• Genetic Background: C57BL/6J-Rel^M1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

impaired hematopoiesis ( J:236682 )

decreased B-1 B cell number ( J:236682 )

decreased CD4-positive, alpha-beta T cell number ( J:236682 )

• naive CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:236682 )

• naive CD8+ T cells

increased T cell number ( J:236682 )

increased CD4-positive, alpha-beta T cell number ( J:236682 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:236682 )

increased CD8-positive, alpha-beta T cell number ( J:236682 )

decreased IgE level ( J:236682 )

• reduced OVA-specific IgE/total IgE after injection of ovalbumin administered with aluminum hydroxide

decreased IgG level ( J:236682 )

• reduced T-dependent antibody responses to ovalbumin administered with aluminum hydroxide

decreased IgM level ( J:236682 )

• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

immune system

decreased B-1 B cell number ( J:236682 )

decreased CD4-positive, alpha-beta T cell number ( J:236682 )

• naive CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:236682 )

• naive CD8+ T cells

increased T cell number ( J:236682 )

increased CD4-positive, alpha-beta T cell number ( J:236682 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:236682 )

increased CD8-positive, alpha-beta T cell number ( J:236682 )

decreased IgE level ( J:236682 )

• reduced OVA-specific IgE/total IgE after injection of ovalbumin administered with aluminum hydroxide

decreased IgG level ( J:236682 )

• reduced T-dependent antibody responses to ovalbumin administered with aluminum hydroxide

decreased IgM level ( J:236682 )

• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

decreased response to antigen ( J:236682 )

• reduced OVA-specific IgE/total IgE after injection of ovalbumin administered with aluminum hydroxide

• reduced T-dependent antibody responses to ovalbumin administered with aluminum hydroxide

• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

Genotype
MGI:5807166

ht2

• Allelic Composition: Rel^M1Btlr/Rel⁺
• Genetic Background: C57BL/6J-Rel^M1Btlr

hematopoietic system

impaired hematopoiesis ( J:236682 )

• slight

increased T cell number ( J:236682 )

increased CD4-positive, alpha-beta T cell number ( J:236682 )

decreased IgE level ( J:236682 )

• reduced OVA-specific IgE/total IgE after injection of ovalbumin administered with aluminum hydroxide

decreased IgG level ( J:236682 )

• reduced T-dependent antibody responses to ovalbumin administered with aluminum hydroxide

decreased IgM level ( J:236682 )

• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

immune system

increased T cell number ( J:236682 )

increased CD4-positive, alpha-beta T cell number ( J:236682 )

decreased IgE level ( J:236682 )

• reduced OVA-specific IgE/total IgE after injection of ovalbumin administered with aluminum hydroxide

decreased IgG level ( J:236682 )

• reduced T-dependent antibody responses to ovalbumin administered with aluminum hydroxide

decreased IgM level ( J:236682 )

• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll

decreased response to antigen ( J:236682 )

• reduced OVA-specific IgE/total IgE after injection of ovalbumin administered with aluminum hydroxide

• reduced T-dependent antibody responses to ovalbumin administered with aluminum hydroxide

• reduced T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll