All Phenotypes Ica1l<em1Jxia> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ica1l^em1Jxia
endonuclease-mediated mutation 1, Jun Xia
MGI:5806150

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ica1l^em1Jxia/Ica1l^em1Jxia	involves: C57BL/6 * CBA	MGI:5806227
cx2	Ica1^tm1Mdos/Ica1^tm1Mdos Ica1l^em1Jxia/Ica1l^em1Jxia	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:5806228

Allelic Composition	Ica1l^em1Jxia/Ica1l^em1Jxia
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1l^em1Jxia mutation (0 available); any Ica1l mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal sperm mitochondrial sheath morphology ( J:233657 )

oligozoospermia ( J:233657 )

• in the cauda epididymis

• reduced mobile and linear mobile sperm form the cauda epididymis

abnormal sperm nucleus morphology ( J:233657 )

• smaller and irregular compared with wild-type sperm

abnormal spermiogenesis ( J:233657 )

• with round nuclei sperm

globozoospermia ( J:233657 )

decreased litter size ( J:233657 )

• reduced litter size produced from male mice

reduced male fertility ( J:233657 )

• with reduced litter size

cellular

abnormal sperm mitochondrial sheath morphology ( J:233657 )

oligozoospermia ( J:233657 )

• in the cauda epididymis

• reduced mobile and linear mobile sperm form the cauda epididymis

globozoospermia ( J:233657 )

abnormal sperm nucleus morphology ( J:233657 )

• smaller and irregular compared with wild-type sperm

Allelic Composition	Ica1^tm1Mdos/Ica1^tm1Mdos Ica1l^em1Jxia/Ica1l^em1Jxia
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1l^em1Jxia mutation (0 available); any Ica1l mutation (23 available)
Ica1^tm1Mdos mutation (1 available); any Ica1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal sperm mitochondrial sheath morphology ( J:233657 )

oligozoospermia ( J:233657 )

• severe reduction in total and mobile sperm number with complete loss of linear mobile sperm

• in cauda epididymis

abnormal acrosome morphology ( J:233657 )

• fragmented or completely lost

globozoospermia ( J:233657 )

absent acrosome ( J:233657 )

• in some sperm

abnormal sperm nucleus morphology ( J:233657 )

• smaller and irregular compared with wild-type sperm

abnormal spermiogenesis ( J:233657 )

• with round nuclei sperm

male infertility ( J:233657 )

cellular

abnormal sperm mitochondrial sheath morphology ( J:233657 )

oligozoospermia ( J:233657 )

• severe reduction in total and mobile sperm number with complete loss of linear mobile sperm

• in cauda epididymis

abnormal acrosome morphology ( J:233657 )

• fragmented or completely lost

globozoospermia ( J:233657 )

absent acrosome ( J:233657 )

• in some sperm

abnormal sperm nucleus morphology ( J:233657 )

• smaller and irregular compared with wild-type sperm

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24