Ica1l^em1Jxia
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ica1l^em1Jxia
• Name: islet cell autoantigen 1-like; endonuclease-mediated mutation 1, Jun Xia
• MGI ID: MGI:5806150
• Gene: Ica1l Location: Chr1:60024955-60082646 bp, - strand Genetic Position: Chr1, 30.45 cM, cytoband C2
• Alliance: Ica1l^em1Jxia page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F2

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Not Specified
• Mutation details: CRISPR/Cas technology targeted exon 2 to generate a knock-out allele lacking 23 nucleotides. Western blot analysis confirmed an 80% reduction in protein levels in the testes. (J:233657)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ica1l Mutation: 23 strains or lines available

References

• Original: J:233657 He J, et al., ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. J Cell Sci. 2015 Oct 15;128(20):3822-36
• All: 1 reference(s)