About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Phlpp2tm1d(EUCOMM)Hmgu
targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
MGI:5795604
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Phlpp2tm1d(EUCOMM)Hmgu/Phlpp2tm1d(EUCOMM)Hmgu involves: C57BL/6N MGI:5795608
cx2
 		Phlpp1tm1.1Saco/Phlpp1tm1.1Saco
Phlpp2tm1d(EUCOMM)Hmgu/Phlpp2tm1d(EUCOMM)Hmgu 		involves: 129 * C57BL/6N MGI:5795607


Genotype
MGI:5795608
hm1
Allelic
Composition		 Phlpp2tm1d(EUCOMM)Hmgu/Phlpp2tm1d(EUCOMM)Hmgu
Genetic
Background		 involves: C57BL/6N
Cell Lines HEPD0619_1_C08
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phlpp2tm1d(EUCOMM)Hmgu mutation (0 available); any Phlpp2 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:231241 )
N
• mice exhibit normal susceptibility to DSS-induced colitis

immune system
immune system phenotype ( J:231241 )
N
• mice exhibit normal susceptibility to DSS-induced colitis




Genotype
MGI:5795607
cx2
Allelic
Composition		 Phlpp1tm1.1Saco/Phlpp1tm1.1Saco
Phlpp2tm1d(EUCOMM)Hmgu/Phlpp2tm1d(EUCOMM)Hmgu
Genetic
Background		 involves: 129 * C57BL/6N
Cell Lines HEPD0619_1_C08
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phlpp1tm1.1Saco mutation (0 available); any Phlpp1 mutation (52 available)
Phlpp2tm1d(EUCOMM)Hmgu mutation (0 available); any Phlpp2 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased susceptibility to induced colitis ( J:231241 )
• DSS-treated mice exhibit reduced weight loss, colonic epithelial damage or crypt damage, macrophage infiltration, epithelial cell apoptosis and reduction in colon length compared with wild-type mice

growth/size/body
decreased susceptibility to weight loss ( J:231241 )
• in DSS-treated mice

immune system
decreased susceptibility to induced colitis ( J:231241 )
• DSS-treated mice exhibit reduced weight loss, colonic epithelial damage or crypt damage, macrophage infiltration, epithelial cell apoptosis and reduction in colon length compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory