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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ell2tm2.1Cmil
targeted mutation 2.1, Christine Milcarek
MGI:5792877
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd19tm1(cre)Cgn/Cd19+
Ell2tm2.1Cmil/Ell2tm2.1Cmil 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:5793062


Genotype
MGI:5793062
cn1
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Ell2tm2.1Cmil mutation (0 available); any Ell2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased mature B cell number ( J:234692 )
• decrease in IgG1-producing cells in bone marrow from unimmunized mice; these cells may represent either plasma cells or memory B cells
decreased immunoglobulin level ( J:234692 )
• decrease in serum levels of secreted IgM, IgG1, IgA and all other IgG isotypes is found in naive mice as compared to controls

immune system
decreased mature B cell number ( J:234692 )
• decrease in IgG1-producing cells in bone marrow from unimmunized mice; these cells may represent either plasma cells or memory B cells
decreased immunoglobulin level ( J:234692 )
• decrease in serum levels of secreted IgM, IgG1, IgA and all other IgG isotypes is found in naive mice as compared to controls




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory