Analysis Tools
behavior/neurological
 N |
• mice exhibit normal exploratory behavior, no changes in basal anxiety, normal motor coordination on the rotarod, and normal contextual fear conditioning
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• while the escape latency throughout 6 days of training in the Morris Water Maze is similar to wild-type mice, during the subsequent memory test, mutants show increased preference for the target region compared to wild-type mice
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cellular
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N |
• mice show unaltered intraneuronal mitochondrial trafficking in primary hippocampal neurons in response to amyloid beta-derived diffusible ligands compared to wild-type controls which show progressive impairment of mitochondrial trafficking
• mice show normal immunoreactivity to Tom20, a marker for mitochondrial localization, in the soma, indicating normal mitochondrial trafficking
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nervous system
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N |
• gross brain morphology, brain mass, and body mass are normal
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