Hdac6^tm1Anfi
Targeted Allele Detail

Summary

• Symbol: Hdac6^tm1Anfi
• Name: histone deacetylase 6; targeted mutation 1, Andre Fischer
• MGI ID: MGI:5792141
• Gene: Hdac6 Location: ChrX:7796359-7814128 bp, - strand Genetic Position: ChrX, 3.58 cM
• Alliance: Hdac6^tm1Anfi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234763
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exons 10-13. Semi-quantitative PCR and immunoblot analysis confirmed absence of mRNA and protein levels in the hippocampus and cortex of homozygotes. (J:234763)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac6 Mutation: 14 strains or lines available

References

• Original: J:234763 Govindarajan N, et al., Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease. EMBO Mol Med. 2013 Jan;5(1):52-63
• All: 1 reference(s)