Phenotypes associated with this allele

• Allele Symbol: Ell2^tm1.1Cmil
• Allele Name: targeted mutation 1.1, Christine Milcarek
• Allele ID: MGI:5790670
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd19^tm1(cre)Cgn/Cd19^+ Ell2^tm1.1Cmil/Ell2^tm1.1Cmil	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5793061

Genotype
MGI:5793061

cn1

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Ell2^tm1.1Cmil/Ell2^tm1.1Cmil
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased transitional stage T1 B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH) fewer T1 and T2 type B cells are observed in spleen

decreased transitional stage T2 B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH) fewer T1 and T2 type B cells are observed in spleen

decreased transitional stage T3 B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH) fewer T3 cells are observed in spleen

increased immature B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH) percentage of immature B cells in bone marrow is increased as compared to control

increased pro-B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH)

decreased mature B cell number ( J:234692 )

• decrease in IgG1-producing cells in bone marrow from unimmunized mice; these cells may represent either plasma cells or memory B cells

decreased plasma cell number ( J:234692 )

• 4 fold decrease in LPS-treated B220^loCD138⁺ splenic B cells

• decline in CD138+ cells in immunized mice

increased follicular B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH) percentage of recirculating B cells in bone marrow is increased as compared to control

increased pre-B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH)

decreased immunoglobulin level ( J:234692 )

• 2 fold decrease in serum levels of secreted IgM, IgG1, IgA and all other IgG isotopes is found in naive mice as compared to controls

decreased IgA level ( J:234692 )

decreased IgG1 level ( J:234692 )

decreased IgM level ( J:234692 )

impaired humoral immune response ( J:234692 )

• specific antibody responses are impaired for both T cell dependent and independent antigens

• mice immunized with NP-Ficoll exhibit less anti-NP antibody of the IgM, IgG2b and IgG3 isotypes

• mice immunized with NP-KLH exhibit less anti-NP antibody of the IgM, IgG1, IgG2c and IgG3 isotopes

• following restimulation, recall response is less than controls

hematopoietic system

decreased transitional stage T1 B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH) fewer T1 and T2 type B cells are observed in spleen

decreased transitional stage T2 B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH) fewer T1 and T2 type B cells are observed in spleen

decreased transitional stage T3 B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH) fewer T3 cells are observed in spleen

increased immature B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH) percentage of immature B cells in bone marrow is increased as compared to control

increased pro-B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH)

decreased mature B cell number ( J:234692 )

• decrease in IgG1-producing cells in bone marrow from unimmunized mice; these cells may represent either plasma cells or memory B cells

decreased plasma cell number ( J:234692 )

• 4 fold decrease in LPS-treated B220^loCD138⁺ splenic B cells

• decline in CD138+ cells in immunized mice

increased follicular B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH) percentage of recirculating B cells in bone marrow is increased as compared to control

increased pre-B cell number ( J:234692 )

• following antigen challenge (NP-Ficoll or NP-KLH)

decreased immunoglobulin level ( J:234692 )

• 2 fold decrease in serum levels of secreted IgM, IgG1, IgA and all other IgG isotopes is found in naive mice as compared to controls

decreased IgA level ( J:234692 )

decreased IgG1 level ( J:234692 )

decreased IgM level ( J:234692 )

cellular

abnormal endoplasmic reticulum morphology ( J:234692 )

• ER found in LPS-treated B220^loCD138⁺ cells is dilated and fragmented