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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hotairtm1Vlcg
targeted mutation 1, Velocigene
MGI:5790422
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hotairtm1Vlcg/Hotairtm1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac MGI:5812375


Genotype
MGI:5812375
hm1
Allelic
Composition		 Hotairtm1Vlcg/Hotairtm1Vlcg
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hotairtm1Vlcg mutation (0 available); any Hotair mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Homeotic transformation in the 4th caudal vertebra of Hotairtm1Vlcg/Hotairtm1Vlcg mice

limbs/digits/tail
abnormal hindlimb morphology ( J:233815 )
• adult mice show morphologic malformations in the hindlimbs
abnormal tail morphology ( J:233815 )
• adult mice show morphologic malformations in the tail
caudal vertebral transformation ( J:233815 )
• adult mice show a homeotic transformation of the 4th caudal vertebra to a structure similar to that of 3rd caudal vertebra

skeleton
caudal vertebral transformation ( J:233815 )
• adult mice show a homeotic transformation of the 4th caudal vertebra to a structure similar to that of 3rd caudal vertebra




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory