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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp3cctm1.1Osb
targeted mutation 1.1, Research Institute for Microbial Diseases, Osaka University
MGI:5788175
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppp3cctm1.1Osb/Ppp3cctm1.1Osb involves: C57BL/6 * DBA/2 MGI:5788185


Genotype
MGI:5788185
hm1
Allelic
Composition		 Ppp3cctm1.1Osb/Ppp3cctm1.1Osb
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cctm1.1Osb mutation (0 available); any Ppp3cc mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:226539 )
N
• no overt abnormalities in spermatogenesis, epididymal sperm morphology or sperm counts
• the principal piece of the spermatozoa is normal
abnormal sperm midpiece morphology ( J:226539 )
• slightly bent in the opposite direction from the acrosome hook and inflexible
male infertility ( J:226539 )
• with fewer spermatozoa reaching the ampulla than in wild-type mice
impaired fertilization ( J:226539 )
• in vitro, spermatozoa fail to fertilize cumulus-intact and cumulus-free zona pellucida intact oocytes
• however, sperm can pass through the cumulus cell layer and bind to the zona pellucida and can fertilize zona pellucida-free oocytes

cellular
abnormal sperm midpiece morphology ( J:226539 )
• slightly bent in the opposite direction from the acrosome hook and inflexible




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory