Ppp3cctm1.1Osb
Targeted Allele Detail
|
Symbol: |
Ppp3cctm1.1Osb |
Name: |
protein phosphatase 3, catalytic subunit, gamma isoform; targeted mutation 1.1, Research Institute for Microbial Diseases, Osaka University |
MGI ID: |
MGI:5788175 |
Synonyms: |
Ppp3cctm1a(EUCOMM)Osb |
Gene: |
Ppp3cc Location: Chr14:70455314-70526920 bp, - strand Genetic Position: Chr14, 36.3 cM
|
Alliance: |
Ppp3cctm1.1Osb page
|
|
|
Allele Type: |
|
Targeted (Null/knockout, Reporter) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A IKMC vector (design ID:85228) inserted an FRT site, lacZ reporter gene, loxP site, neomycin resistance cassette, FRT site and loxP site upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and exon 3. Western blot analysis confirmed the absence of protein expression in the testis and sperm.
(J:226539)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Ppp3cc Mutation: |
31 strains or lines available
|
|
Original: |
J:226539 Miyata H, et al., Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive. Science. 2015 Oct 23;350(6259):442-5 |
All: |
1 reference(s) |
|