Analysis Tools
liver/biliary system
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• after induction with tamoxifen and partial hepatectomy, Hcfc1-negative cells do not display cell proliferation markers
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Allele Symbol Allele Name Allele ID |
Hcfc1tm1Lwh targeted mutation 1, Winship Herr MGI:5787629 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after induction with tamoxifen and partial hepatectomy, Hcfc1-negative cells do not display cell proliferation markers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E9.5 male embryos much smaller in size and morphologically abnormal
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• at E9.5 male embryos much smaller in size and morphologically abnormal
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• male embryos died between E5.5 and E9.5
• at E12.5 male embryos found at resorption sites
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• no males born
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in E7.5 embryos with maternally inherited conditional knockout allele
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• reduced presence of cell proliferation markers in E7.5 embryos with maternally inherited conditional knockout allele
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• of E7.5 embryos with maternally inherited conditional knockout allele
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• of E7.5 embryos with maternally inherited conditional knockout allele
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• of E7.5 embryos with maternally inherited conditional knockout allele
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• in females with a maternally inherited conditional knockout allele
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• in females with maternally inherited conditional knockout allele
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• no female embryos with maternally inherited conditional knockout allele found at E7.5
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• no females born with maternally inherited conditional knockout allele
• females with paternally inherited conditional knockout allele viable
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in E7.5 embryos
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• reduced presence of cell proliferation markers in E7.5 embryos
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• of E7.5 embryos
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• of E7.5 embryos
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• of E7.5 embryos
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• no female embryos found at E7.5
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• no females born
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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