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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sav1tm1.1Gpp
targeted mutation 1.1, Gerd P Pfeifer
MGI:5784888
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sav1tm1.1Gpp/Sav1tm1.1Gpp involves: 129S1/Sv MGI:5784894
ht2
 		Sav1tm1.1Gpp/Sav1+ involves: 129S1/Sv MGI:5784895
cx3
 		Rassf1tm1Gpp/Rassf1tm1Gpp
Sav1tm1.1Gpp/Sav1+ 		involves: 129S1/Sv * 129S1/SvImJ MGI:5784899


Genotype
MGI:5784894
hm1
Allelic
Composition		 Sav1tm1.1Gpp/Sav1tm1.1Gpp
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1tm1.1Gpp mutation (0 available); any Sav1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:231761 )
• complete embryonic lethality; time not specified




Genotype
MGI:5784895
ht2
Allelic
Composition		 Sav1tm1.1Gpp/Sav1+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1tm1.1Gpp mutation (0 available); any Sav1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
bile duct hyperplasia ( J:231761 )
• about 12% of mice show bile duct hyperplasia compared to about 7% of wild-type mice

liver/biliary system
bile duct hyperplasia ( J:231761 )
• about 12% of mice show bile duct hyperplasia compared to about 7% of wild-type mice
abnormal oval cell morphology ( J:231761 )
• more than 50% of mice show signs of oval cell hyperplasia
increased liver tumor incidence ( J:231761 )
• 96% of mice exhibit liver tumors after 1 year of age
increased hepatocellular carcinoma incidence ( J:231761 )
• 71.4% of mice exhibit hepatocellular carcinoma
• 28.6% of mice exhibit mixed hepatocellular carcinoma
increased liver adenoma incidence ( J:231761 )
• 65.3% of mice exhibit hepatocellular adenoma
• 34.7% of mice exhibit mixed hepatocellular adenoma

neoplasm
increased liver tumor incidence ( J:231761 )
• 96% of mice exhibit liver tumors after 1 year of age
increased hepatocellular carcinoma incidence ( J:231761 )
• 71.4% of mice exhibit hepatocellular carcinoma
• 28.6% of mice exhibit mixed hepatocellular carcinoma
increased liver adenoma incidence ( J:231761 )
• 65.3% of mice exhibit hepatocellular adenoma
• 34.7% of mice exhibit mixed hepatocellular adenoma




Genotype
MGI:5784899
cx3
Allelic
Composition		 Rassf1tm1Gpp/Rassf1tm1Gpp
Sav1tm1.1Gpp/Sav1+
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rassf1tm1Gpp mutation (0 available); any Rassf1 mutation (26 available)
Sav1tm1.1Gpp mutation (0 available); any Sav1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
bile duct hyperplasia ( J:231761 )
• about 15-20% of mice show bile duct hyperplasia compared to about 7% of wild-type mice

liver/biliary system
bile duct hyperplasia ( J:231761 )
• about 15-20% of mice show bile duct hyperplasia compared to about 7% of wild-type mice
abnormal oval cell morphology ( J:231761 )
• more than 50% of mice show signs of oval cell hyperplasia
increased liver tumor incidence ( J:231761 )
• 90% of mice develop liver tumors
increased hepatoblastoma incidence ( J:231761 )
• 2.6% of mice exhibit hepatoblastoma
increased hepatocellular carcinoma incidence ( J:231761 )
• 77% of mice exhibit hepatocellular carcinoma
• 23.1% of mice exhibit mixed hepatocellular carcinoma
increased liver adenoma incidence ( J:231761 )
• 79.5% of mice exhibit hepatocellular adenoma
• 38.5% of mice exhibit mixed hepatocellular adenoma

neoplasm
increased liver tumor incidence ( J:231761 )
• 90% of mice develop liver tumors
increased hepatoblastoma incidence ( J:231761 )
• 2.6% of mice exhibit hepatoblastoma
increased hepatocellular carcinoma incidence ( J:231761 )
• 77% of mice exhibit hepatocellular carcinoma
• 23.1% of mice exhibit mixed hepatocellular carcinoma
increased liver adenoma incidence ( J:231761 )
• 79.5% of mice exhibit hepatocellular adenoma
• 38.5% of mice exhibit mixed hepatocellular adenoma




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory