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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Or8a1tm39(Gnas*)Mom
targeted mutation 39, Peter Mombearts
MGI:5784884
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Or8a1tm39(Gnas*)Mom/Or8a1+ B6;129P2-Or8a1tm39(Gnas*)Mom/MomJ MGI:5788650


Genotype
MGI:5788650
ht1
Allelic
Composition
Or8a1tm39(Gnas*)Mom/Or8a1+
Genetic
Background
B6;129P2-Or8a1tm39(Gnas*)Mom/MomJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm39(Gnas*)Mom mutation (1 available); any Or8a1 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
taste/olfaction
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

craniofacial
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

nervous system
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

growth/size/body
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

respiratory system
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory