Analysis Tools
normal phenotype
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• adult homozygotes are viable and fertile and do not exhibit any overt phenotypes
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Allele Symbol Allele Name Allele ID |
Gli3tm3.1Blnw targeted mutation 3.1, Baolin Wang MGI:5780889 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• adult homozygotes are viable and fertile and do not exhibit any overt phenotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ~50% of mice display hindlimb autopods with fused digits, while the rest have normal hindlimb autopods
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• E16.5 forelimb autopods are much smaller than those in control mice
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• forelimb digits are shorter
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• at E16.5, forelimb digit number varies from 3 to 5, with some digits fused (oligosyndactyly)
• at E16.5, two of 5 mice show normal hindlimb autopods, while the rest show 3 to 5 digits, some of which are fused or partial
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• forelimb digits are fused and shorter, making it difficult to determine digit number
• ~50% of mice display hindlimb autopods with fused digits
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• at E16.5, the humerus is slightly shorter than that in wild-type controls
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• at E16.5, the forelimb zeugopod elements, radius and ulna, are bent and much shorter than those in control mice
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• at E16.5
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• at E16.5, the radius is much shorter than that in wild-type controls
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• at E16.5
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• at E16.5, the ulna is much shorter than that in wild-type controls
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• adult and E16.5 forelimbs are markedly shorter with consistently smaller autopods than those in control mice
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• ~50% of adult and E16.5 mice display hindlimb autopods with fused digits
• however, hindlimb length is normal
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• at E16.5, the femur is slightly shorter than that in wild-type controls
• however, patterning appears normal
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• at E16.5, the fibula is slightly shorter than that in wild-type controls
• however, patterning appears normal
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• at E16.5, the tibia is slightly shorter than that in wild-type controls
• however, patterning appears normal
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• at E16.5, the humerus is slightly shorter than that in wild-type controls
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• at E16.5
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• at E16.5, the radius is much shorter than that in wild-type controls
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• at E16.5
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• at E16.5, the ulna is much shorter than that in wild-type controls
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• at E16.5, the femur is slightly shorter than that in wild-type controls
• however, patterning appears normal
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• at E16.5, the fibula is slightly shorter than that in wild-type controls
• however, patterning appears normal
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• at E16.5, the tibia is slightly shorter than that in wild-type controls
• however, patterning appears normal
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• at E16.5, the distal scapula is slightly shorter than that in wild-type controls
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• at E16.5, forelimb autopods often lack ossification
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all but two mice died before or immediately after birth
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• mice display limb phenotypes that resemble those observed in Shhtm1Chg homozygotes
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• at E16.5, the forelimb autopod lacks all digits and is presented by a single cartilage element
• at E16.5, most hindlimb autopods have 3 identifiable first digits
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• surviving newborns exhibit a single digit in the forelimbs and 1 or 3 digits in the hindlimbs
• at E16.5, most hindlimbs appear to have 3 digits, or occasionally only one
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• at E16.5, the humerus is significantly shorter than that in wild-type controls
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• at E16.5, the forelimb zeugopod is presented by a single bone element and is significantly shorter than that in wild-type controls
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• at E16.5
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• at E16.5
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• at E16.5, the fibula is very short
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• at E16.5, the tibia is very short
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• surviving newborns exhibit extremely short limbs
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• forelimbs are consistently very short with no obvious digit structure, regardless of the age of embryos and newborns
• at E16.5, all forelimb bone elements are shorter than those observed in Shhtm1Chg homozygotes
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• at E16.5, hindlimbs are short, though not as much as the forelimbs
• at E16.5, all hindlimb bone structures are much or slightly shorter than those observed in wild-type controls or Shhtm1Chg homozygotes, respectively
• hindlimb phenotypes are more variable than forelimb phenotypes, most likely due to low levels of cre in the hindlimbs
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• at E16.5, the humerus is significantly shorter than that in wild-type controls
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• at E16.5
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• at E16.5
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• at E16.5, the fibula is very short
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• at E16.5, the tibia is very short
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• at E16.5, the scapula is significantly shorter than that in wild-type controls
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• at E16.5, forelimb autopods lack ossification
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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