Phenotypes associated with this allele

• Allele Symbol: Prpf4b^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5779705
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prpf4b^em1(IMPC)J/Prpf4b^em1(IMPC)J	C57BL/6NJ-Prpf4b^em1(IMPC)J/J	MGI:6263245

Genotype
MGI:6263245

hm1

• Allelic Composition: Prpf4b^em1(IMPC)J/Prpf4b^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Prpf4b^em1(IMPC)J/J

Data Sources

IMPC Data for Prpf4b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cell death ( J:279207 )

• early blastocysts/late morulas show apparent cell death after 3 days in culture

absent inner cell mass proliferation ( J:279207 )

• blastocysts fail to form normal outgrowth colonies after 3 days in culture

embryo

absent inner cell mass proliferation ( J:279207 )

• blastocysts fail to form normal outgrowth colonies after 3 days in culture

failure of blastocyst formation ( J:279207 )

• early blastocysts/late morulas recovered at E3.5 fail to reach a morphological blastocyst stage after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in culture, embryos fail to hatch from the zona pellucida with apparent cell death

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at slightly lower than expected Mendelian ratios at E3.5 (18% versus 25%) and appear to arrest/die prior to blastocyst formation; no embryos or excess resorption sites are observed at E7.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX