nervous system
N |
• CA1 pyramidal cell synapses exhibit normal input-output function with normal amplitudes or frequencies of AMPAR-mediated miniature excitatory postsynaptic currents
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• impaired NMDAR-dependent synaptic plasticity at hippocampal Sch-CA1 synapses
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• faster decay of NMDAR-mediated excitatory postsynaptic currents
• reduced sensitivity to Ro25-6981 but increased sensitivity to low doses of zinc, which selectively blocks GluN2B-containing and GluN2A-containing NMDARs
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• reduced NMDAR-dependent long term depression
• however, mGluR(Grm8)-dependent LTD is not affected
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