Analysis Tools
behavior/neurological
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• impaired motor learning as observed in rotarod test
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• decreased total distance travelled in open field test as compared to controls
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• mice spend less time exploring center of open area test than controls
• mice spend less time in open arm during elevated zero maze test
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• 28% of mice develop lesions from grooming between 4 and 6 months
• mice spend twice as much time grooming as controls
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• impaired acoustic startle response
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• impaired motor coordination in rotarod test
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• reduced number of interactive events in juvenile social play at P23
• nose-to-anogenital sniffing and following behavior are reduced as compared to controls
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• increased social dominance behavior as determined by tube test
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• mice exhibit no preference for a stranger mouse or novel object in a test of voluntary social interaction
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nervous system
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• reduction in spine density of layer 2/3 pyramidal neurons in prefrontal cortex
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• reduced field population spike amplitude in dorsolateral striatum at P14 and adult as compared to controls
• presynaptic function is not affected
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• reduced NMDA receptor-mediated currents as compared to controls
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• increase in mEPSC amplitude in P14 dorsolateral striatal medium spiny neurons, but not frequency, as compared to controls
• no difference in mEPSC frequency or amplitude is found in prefrontal cortex of P14 mice
• reduced mEPSC frequency in medium spiny neurons from adult mice as compared to controls
• small, but significant, reduction of mEPSC amplitude in medium spiny neurons from adult mice as compared to controls
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• reduced paired pulse inhibition (PPI)
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:230887 | ||
