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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ddx3xtm1.1Lyou
targeted mutation 1.1, Li-Ru You
MGI:5774968
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ddx3xtm1.1Lyou/Ddx3x+
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129 * C57BL/6 * CBA MGI:5774973
cn2
 		Ddx3xtm1.1Lyou/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129 * C57BL/6 * CBA MGI:5774972


Genotype
MGI:5774973
cn1
Allelic
Composition		 Ddx3xtm1.1Lyou/Ddx3x+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx3xtm1.1Lyou mutation (0 available); any Ddx3x mutation (10 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:231798 )
• females with loss of expression of the maternal allele in the epiblast but not visceral endoderm and extraembryonic ectoderm are viable with no gross abnormalities




Genotype
MGI:5774972
cn2
Allelic
Composition		 Ddx3xtm1.1Lyou/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx3xtm1.1Lyou mutation (0 available); any Ddx3x mutation (10 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality prior to tooth bud stage ( J:231798 )
• non-viable embryos are detected at E10.5 and E11.5
preweaning lethality, complete penetrance ( J:231798 )
• by weaning no males are detected

embryo
increased embryonic tissue cell apoptosis ( J:231798 )
• in the whole body and allantois before embryo turning
abnormal developmental patterning ( J:231798 )
• deformed caudal embryonic structure at E9.5
abnormal embryo turning ( J:231798 )
• failure of body turning
embryonic growth retardation ( J:231798 )
• developmental delay at E9.5
small allantois ( J:231798 )
• shorter at E9.5
failure of chorioallantoic fusion ( J:231798 )
• at E8.5 in unturned embryos

cellular
abnormal cell physiology ( J:231798 )
• increase in markers of DNA damage
abnormal cell cycle ( J:231798 )
• cell cycle arrest
increased mitotic index ( J:231798 )
• in embryos at E9.5
increased embryonic tissue cell apoptosis ( J:231798 )
• in the whole body and allantois before embryo turning

cardiovascular system

growth/size/body
embryonic growth retardation ( J:231798 )
• developmental delay at E9.5
microcephaly ( J:231798 )

nervous system
abnormal brain development ( J:231798 )
• underdeveloped

homeostasis/metabolism

muscle




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory