Ddx3x^tm1.1Lyou
Targeted Allele Detail

Summary

• Symbol: Ddx3x^tm1.1Lyou
• Name: DEAD box helicase 3, X-linked; targeted mutation 1.1, Li-Ru You
• MGI ID: MGI:5774968
• Synonyms: Ddx3x^flox
• Gene: Ddx3x Location: ChrX:13147261-13160222 bp, + strand Genetic Position: ChrX, 8.17 cM
• Alliance: Ddx3x^tm1.1Lyou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231798
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 3 and an frt-PGK-neo-frt-loxP was inserted in exon 17 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 3-17 floxed. (J:231798)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddx3x Mutation: 6 strains or lines available

References

• Original: J:231798 Chen CY, et al., Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 July 15;25(14):2905-2922
• All: 3 reference(s)