Phenotypes associated with this allele

• Allele Symbol: Reln^tm1.1Mhat
• Allele Name: targeted mutation 1.1, Mitsuharu Hattori
• Allele ID: MGI:5774964
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Reln^tm1.1Mhat/Reln^tm1.1Mhat	B6NSlc.B6(Cg)-Reln^tm1.1Mhat	MGI:5775048

Genotype
MGI:5775048

hm1

• Allelic Composition: Reln^tm1.1Mhat/Reln^tm1.1Mhat
• Genetic Background: B6NSlc.B6(Cg)-Reln^tm1.1Mhat

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:220151 )

N • the cerebral cortex exhibits normal layer structure

abnormal cortical marginal zone morphology ( J:220151 )

• variably narrower than in wild-type mice starting at P5

• narrower in the presumptive somatosensory cortex than the motor cortex

• the marginal zone and primitive marginal zone is disorganized with blurred borders compared to in wild-type mice

• however, width is normal during embryonic stages and distribution of interneurons is normal

abnormal hippocampus morphology ( J:220151 )

abnormal hippocampus CA1 region morphology ( J:220151 )

• split into 2 layers

abnormal dentate gyrus morphology ( J:220151 )

• the dentate granule cell layer is less packed than in wild-type mice

abnormal cerebral cortex morphology ( J:220151 )

• neurons extend into the marginal zone, first evident at P3

• however, localization of neurons in deeper layer are largely normal

behavior/neurological

behavior/neurological phenotype ( J:220151 )

N • unlike the reeler mouse, mice do not exhibit ataxia