Reln^tm1.1Mhat
Targeted Allele Detail

Summary

• Symbol: Reln^tm1.1Mhat
• Name: reelin; targeted mutation 1.1, Mitsuharu Hattori
• MGI ID: MGI:5774964
• Synonyms: deltaC-KI
• Gene: Reln Location: Chr5:22089452-22549700 bp, - strand Genetic Position: Chr5, 9.98 cM, cytoband A3-B1
• Alliance: Reln^tm1.1Mhat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220151
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 65 was replaced with a FLAG epitope, deleting the sequence encoding the C terminal region. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the modified exon 65. Western blot analysis confirmed accumulation of the truncated protein within neurons. (J:220151)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Reln Mutation: 209 strains or lines available

References

• Original: J:220151 Kohno T, et al., Importance of reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis. J Neurosci. 2015 Mar 18;35(11):4776-87
• All: 4 reference(s)