Phenotypes associated with this allele

• Allele Symbol: Mrps34^m1Anu
• Allele Name: mutation 1, Australian National University
• Allele ID: MGI:5763565
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrps34^m1Anu/Mrps34^m1Anu	C57BL/6J-Mrps34^m1Anu	MGI:5763567

Genotype
MGI:5763567

hm1

• Allelic Composition: Mrps34^m1Anu/Mrps34^m1Anu
• Genetic Background: C57BL/6J-Mrps34^m1Anu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal ribosome morphology ( J:222643 )

• instability of the small ribosomal subunit

abnormal mitochondrial ATP synthesis coupled electron transport ( J:222643 )

• decreased mitochondrial respiration and complex activity in the heart and livers

abnormal translation ( J:222643 )

• impaired mitochondrial translation

growth/size/body

cardiac hypertrophy ( J:222643 )

• of the ventricular posterior wall

cardiovascular system

cardiac hypertrophy ( J:222643 )

• of the ventricular posterior wall

increased cardiac muscle contractility ( J:222643 )

liver/biliary system

hepatic steatosis ( J:222643 )

• in young mice and more pronounced in aged mice

liver fibrosis ( J:222643 )

• in young mice and more pronounced in aged mice

homeostasis/metabolism

abnormal translation ( J:222643 )

• impaired mitochondrial translation

increased circulating alanine transaminase level ( J:222643 )

decreased oxygen consumption ( J:222643 )

muscle

increased cardiac muscle contractility ( J:222643 )

centrally nucleated skeletal muscle fibers ( J:222643 )

• in aged mice