All Phenotypes Riox1<tm1Qch> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Riox1^tm1Qch
targeted mutation 1, Qin Chen
MGI:5762848

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Riox1^tm1Qch/Riox1⁺	involves: 129S6/SvEvTac * C57BL/6NCrl	MGI:5762854
cn2	Riox1^tm1Qch/Riox1^tm1Qch Tg(Prrx1-cre)1Cjt/0	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * SJL/J	MGI:5762856

Allelic Composition	Riox1^tm1Qch/Riox1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Riox1^tm1Qch mutation (0 available); any Riox1 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:224562 )

N	• mice exhibit normal body length and weight

Allelic Composition	Riox1^tm1Qch/Riox1^tm1Qch Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Riox1^tm1Qch mutation (0 available); any Riox1 mutation (17 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

thick neurocranium ( J:224562 )

• thicker than in control mice

increased width of hypertrophic chondrocyte zone ( J:224562 )

• at E14.5 and E15.5 in the femur

abnormal bone structure ( J:224562 )

enhanced osteoblast differentiation ( J:224562 )

• increased Sp7+ preosteoblasts and osteoblasts in endochondral and membranous bones

decreased osteoclast cell number ( J:224562 )

increased bone mineral density ( J:224562 )

• at 2 months of age

increased bone volume ( J:224562 )

• at 2 months of age

increased compact bone thickness ( J:224562 )

• at 2 months of age

increased osteoblast cell number ( J:224562 )

increased bone trabecula number ( J:224562 )

• in the femur

increased bone mass ( J:224562 )

abnormal bone ossification ( J:224562 )

• larger primary ossification centers at E14.5 and E15.5 in the femur compared with wild-type mice

abnormal endochondral bone ossification ( J:224562 )

• increased ossification in the limbs

abnormal intramembranous bone ossification ( J:224562 )

• increased ossification in the skull

growth/size/body

increased birth weight ( J:224562 )

increased body weight ( J:224562 )

• at 2 months of age

increased body length ( J:224562 )

• in newborns and at 2 months of age

craniofacial

thick neurocranium ( J:224562 )

• thicker than in control mice

cellular

enhanced osteoblast differentiation ( J:224562 )

• increased Sp7+ preosteoblasts and osteoblasts in endochondral and membranous bones

hematopoietic system

decreased osteoclast cell number ( J:224562 )

immune system

decreased osteoclast cell number ( J:224562 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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