Phenotypes associated with this allele

• Allele Symbol: Stk11ip^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5755625
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk11ip^em1(IMPC)J/Stk11ip^em1(IMPC)J	C57BL/6NJ-Stk11ip^em1(IMPC)J/J	MGI:6263590

Genotype
MGI:6263590

hm1

• Allelic Composition: Stk11ip^em1(IMPC)J/Stk11ip^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Stk11ip^em1(IMPC)J/J

Data Sources

IMPC Data for Stk11ip

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:311895 )

N • mice show normal blood pressure and no apparent differences in heart morphology or function at baseline

decreased response of heart to induced stress ( J:311895 )

♂ • mice show attenuation of isoproterenol (a beta-adrenoreceptor agonist)-induced cardiac hypertrophy, with mice showing lower diastolic interventricular septal thickness, systolic interventricular septal thickness, diastolic and systolic left ventricular posterior wall, ratios of heart weight/body weight and heart weight/tibia length, attenuated hypertrophic myocardial area and cardiomyocyte area, greatly decreased interstitial and perivascular fibrosis, and reduced expression of cardiac hypertrophy-related genes than in wild-type mice

♂ • mice show attenuation of pressure overload-induced cardiac hypertrophy, with mice subjected to transverse aortic constriction showing reduced left ventricular wall thickness, heart weight/body weight ratio, heart weight/tibia length ratio, cardiomyocyte size, and perivascular and interstitial fibrosis and alleviation of the ejection fraction and fractional shortening seen in wild-type mice

♂ • however, mice with ISO-induced or pressure overload-induced cardiac hypertrophy show no difference from wild-type mice in the increase in capillary and arteriolar density

homeostasis/metabolism

decreased response of heart to induced stress ( J:311895 )

♂ • mice show attenuation of isoproterenol (a beta-adrenoreceptor agonist)-induced cardiac hypertrophy, with mice showing lower diastolic interventricular septal thickness, systolic interventricular septal thickness, diastolic and systolic left ventricular posterior wall, ratios of heart weight/body weight and heart weight/tibia length, attenuated hypertrophic myocardial area and cardiomyocyte area, greatly decreased interstitial and perivascular fibrosis, and reduced expression of cardiac hypertrophy-related genes than in wild-type mice

♂ • mice show attenuation of pressure overload-induced cardiac hypertrophy, with mice subjected to transverse aortic constriction showing reduced left ventricular wall thickness, heart weight/body weight ratio, heart weight/tibia length ratio, cardiomyocyte size, and perivascular and interstitial fibrosis and alleviation of the ejection fraction and fractional shortening seen in wild-type mice

♂ • however, mice with ISO-induced or pressure overload-induced cardiac hypertrophy show no difference from wild-type mice in the increase in capillary and arteriolar density

mortality/aging

mortality/aging ( J:311895 )

N • mice are viable

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX