Phenotypes associated with this allele

• Allele Symbol: Dctn6^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5755486
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dctn6^em1(IMPC)J/Dctn6^em1(IMPC)J	C57BL/6NJ-Dctn6^em1(IMPC)J/J	MGI:6262259

Genotype
MGI:6262259

hm1

• Allelic Composition: Dctn6^em1(IMPC)J/Dctn6^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Dctn6^em1(IMPC)J/J

Data Sources

IMPC Data for Dctn6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cell death ( J:279207 )

• blastocysts show apparent cell death after 3 days in culture

absent inner cell mass proliferation ( J:279207 )

• cultured blastocysts fail to form a typical outgrowth colony

embryo

absent inner cell mass proliferation ( J:279207 )

• cultured blastocysts fail to form a typical outgrowth colony

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• blastocysts fail to hatch from the zona pellucida with apparent cell death after 3 days in culture

absent embryonic epiblast ( J:279207 )

• no epiblast cells are observed after 3 days in culture

absent primitive endoderm ( J:279207 )

• no primitive endoderm (PrE) cells are observed after 3 days in culture

absent trophectoderm ( J:279207 )

• no trophectoderm (TE) is observed after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

embryonic lethality at implantation, complete penetrance ( J:279207 )

• normal blastocysts are present at lower than expected Mendelian ratios at E3.5 (15% versus 25%); no embryos or excess resorption sites are observed at E7.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX