Phenotypes associated with this allele

• Allele Symbol: Dctn6^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5755486
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dctn6^em1(IMPC)J/Dctn6^em1(IMPC)J	C57BL/6NJ-Dctn6^em1(IMPC)J/J	MGI:6262259
ht2	Dctn6^em1(IMPC)J/Dctn6^+	C57BL/6NJ-Dctn6^em1(IMPC)J/J	MGI:7628960

Genotype
MGI:6262259

hm1

• Allelic Composition: Dctn6^em1(IMPC)J/Dctn6^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Dctn6^em1(IMPC)J/J

Data Sources

IMPC Data for Dctn6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dctn6^em1(IMPC)J/Dctn6^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as normal blastocysts but not at E7.5. Blastocysts grown in culture fail to hatch from the zona pellucida and to form a typical outgrowth colony.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• blastocysts fail to hatch from the zona pellucida with apparent cell death after 3 days in culture

absent embryonic epiblast ( J:279207 )

• no epiblast cells are observed after 3 days in culture

absent primitive endoderm ( J:279207 )

• no primitive endoderm (PrE) cells are observed after 3 days in culture

absent trophectoderm ( J:279207 )

• no trophectoderm (TE) is observed after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality before implantation, complete penetrance ( J:279207 )

• normal blastocysts are present at lower than expected Mendelian ratios at E3.5 (15% versus 25%, n=33); no embryos or excess resorption sites are observed at E7.5

reproductive system

failure of embryo implantation ( J:279207 )

• blastocysts fail to hatch and form a typical outgrowth colony after 3 days in culture (no TE/PrE/epiblast)

Genotype
MGI:7628960

ht2

• Allelic Composition: Dctn6^em1(IMPC)J/Dctn6⁺
• Genetic Background: C57BL/6NJ-Dctn6^em1(IMPC)J/J

Data Sources

IMPC Data for Dctn6

nervous system

decreased prepulse inhibition ( J:211773 )

♀

IMPC - JAX