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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Brd7tm1.2Ligy
targeted mutation 1.2, Guiyuan Li
MGI:5755484
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Brd7tm1.2Ligy/Brd7tm1.2Ligy involves: 129S4/SvJaeSor * C57BL/6J * FVB/N MGI:6758257
hm2
Brd7tm1.2Ligy/Brd7tm1.2Ligy involves: C57BL/6 MGI:5755485


Genotype
MGI:6758257
hm1
Allelic
Composition
Brd7tm1.2Ligy/Brd7tm1.2Ligy
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brd7tm1.2Ligy mutation (0 available); any Brd7 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• with absent or deformed acrosome
• absent or deformed acrosome

homeostasis/metabolism
N
• mice exhibit normal levels of serum testosterone, estradiol hormone, and follicle-stimulating hormone

endocrine/exocrine glands

cellular
• with absent or deformed acrosome
• absent or deformed acrosome




Genotype
MGI:5755485
hm2
Allelic
Composition
Brd7tm1.2Ligy/Brd7tm1.2Ligy
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brd7tm1.2Ligy mutation (0 available); any Brd7 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal anxiety and depression behaviors in an open field, light-dark box or forced swim test
• decreased discrimination ratio
• decreased discrimination ratio
• increased latency to reach the platform during training and latency to cross the platform on the test day in a Morris water maze test
• mice exhibit reduced entries in the platform zone on test day in a Morris water maze test compared with wild-type mice
• mice spend less time in the new arm of a Y-maze compared with wild-type mice
• however, number of entries in a Y-maze is normal
• mice spend less time in the social target side compared with wild-type mice

nervous system
N
• mice exhibit normal neuron survival
• reduced apical dendritic branching, basal dendritic branching and basal dendritic spines in the medial prefrontal cortex
• however, mice exhibit normal apical dendritic branching, basal dendritic branching, apical dendrite spines and basal dendrite spines in the hippocampus





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory