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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ap2s1em1(IMPC)Tcp
endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI:5754583
Summary 4 genotypes


Genotype
MGI:6408241
hm1
Allelic
Composition		 Ap2s1em1(IMPC)Tcp/Ap2s1em1(IMPC)Tcp
Genetic
Background		 C57BL/6N-Ap2s1em1(IMPC)Tcp/Tcp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap2s1em1(IMPC)Tcp mutation (1 available); any Ap2s1 mutation (11 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6378431
hm2
Allelic
Composition		 Ap2s1em1(IMPC)Tcp/Ap2s1em1(IMPC)Tcp
Genetic
Background		 C57BL/6NCrl-Ap2s1em1(IMPC)Tcp/Tcp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap2s1em1(IMPC)Tcp mutation (1 available); any Ap2s1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality prior to organogenesis ( J:279207 )
• homozygous embryos are recovered at lower than expected Mendelian ratios at E7.5 (10% versus 25%) and arrest prior to gastrulation
embryonic lethality, complete penetrance ( J:279207 )
• no homozygous embryos are recovered at E9.5

embryo
failure to gastrulate ( J:279207 )
• no morphological hallmarks typical of gastrulating embryos are observed at E7.5
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5
abnormal egg cylinder morphology ( J:279207 )
• a rudimentary egg cylinder is observed at E7.5
absent head fold ( J:279207 )
• no head folds are present at E7.5
absent primitive node ( J:279207 )
• no embryonic node is present at E7.5
failure of primitive streak formation ( J:279207 )
• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5




Genotype
MGI:7551044
hm3
Allelic
Composition		 Ap2s1em1(IMPC)Tcp/Ap2s1em1(IMPC)Tcp
Genetic
Background		 C57BL/6NCrl-Ap2s1em1(IMPC)Tcp/Tcp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap2s1em1(IMPC)Tcp mutation (1 available); any Ap2s1 mutation (11 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6261880
ht4
Allelic
Composition		 Ap2s1em1(IMPC)Tcp/Ap2s1+
Genetic
Background		 C57BL/6NCrl-Ap2s1em1(IMPC)Tcp/Tcp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap2s1em1(IMPC)Tcp mutation (1 available); any Ap2s1 mutation (11 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:211773 )
IMPC - UCD

digestive/alimentary system
enlarged cecum ( J:211773 )
IMPC - UCD

growth/size/body
enlarged heart ( J:211773 )
IMPC - UCD
decreased body length ( J:211773 )
IMPC - UCD

nervous system

reproductive system
hydrometra ( J:211773 )
IMPC - UCD




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory