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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gsk3atm1.2Svij
targeted mutation 1.2, Srinivasan Vijayaraghavan
MGI:5752934
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gsk3atm1.2Svij/Gsk3atm1.2Svij involves: 129S4/SvJaeSor * C57BL/6 MGI:6456856
ht2
 		Gsk3atm1.2Svij/Gsk3a+ involves: 129S4/SvJaeSor * C57BL/6 MGI:6456857


Genotype
MGI:6456856
hm1
Allelic
Composition		 Gsk3atm1.2Svij/Gsk3atm1.2Svij
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3atm1.2Svij mutation (0 available); any Gsk3a mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm midpiece morphology ( J:221688 )
• bent in epididymal, but not in testicular, sperm
abnormal sperm head morphology ( J:221688 )
• bent in epididymal, but not in testicular, sperm
asthenozoospermia ( J:221688 )
• reduced percent and progressive motility and velocity parameters with reduced flagellar beat amplitude
male infertility ( J:221688 )
• male mice produce no offspring

cellular
abnormal sperm midpiece morphology ( J:221688 )
• bent in epididymal, but not in testicular, sperm
abnormal sperm head morphology ( J:221688 )
• bent in epididymal, but not in testicular, sperm
asthenozoospermia ( J:221688 )
• reduced percent and progressive motility and velocity parameters with reduced flagellar beat amplitude




Genotype
MGI:6456857
ht2
Allelic
Composition		 Gsk3atm1.2Svij/Gsk3a+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3atm1.2Svij mutation (0 available); any Gsk3a mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:221688 )
N
• male mice exhibit normal fertility
abnormal sperm midpiece morphology ( J:221688 )
• bent in epididymal, but not in testicular, sperm
abnormal sperm head morphology ( J:221688 )
• bent in epididymal, but not in testicular, sperm

cellular
abnormal sperm midpiece morphology ( J:221688 )
• bent in epididymal, but not in testicular, sperm
abnormal sperm head morphology ( J:221688 )
• bent in epididymal, but not in testicular, sperm




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory