Phenotypes associated with this allele

• Allele Symbol: Nlrp6^tm1Opaz
• Allele Name: targeted mutation 1, Nelson Ruiz-Opazo
• Allele ID: MGI:5752293
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlrp6^tm1Opaz/Nlrp6^tm1Opaz	B6.Cg-Nlrp6^tm1Opaz	MGI:5784667

Genotype
MGI:5784667

hm1

• Allelic Composition: Nlrp6^tm1Opaz/Nlrp6^tm1Opaz
• Genetic Background: B6.Cg-Nlrp6^tm1Opaz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased systemic arterial systolic blood pressure ( J:220441 )

• reduced systolic blood pressure in both male and female mice at 6 months of age relative to age- and sex-matched wild-type controls

• however, heart rate is normal

behavior/neurological

behavior/neurological phenotype ( J:220441 )

N • both male and female mice show normal cued task and acquisition performance, as determined by the mean distance traveled on a visible version and on the hidden version of the Morris water maze test

abnormal associative learning ( J:220441 )

• at 4 months of age, male mice fail to recognize a trained odor at 72 h retention time in the social transmission of food preference (STFP) test, unlike wild-type males which recognize the trained odor at 24 h and 72 h

• in contrast, female mice recognize the trained odor at 24 h retention time, unlike wild-type females which fail to distinguish trained from non-trained odors

enhanced spatial learning ( J:220441 )

♀ • at 3 months of age, female mice perform better than wild-type females by showing target selectivity and decreased latency to target counter in the Morris water maze test

impaired spatial learning ( J:220441 )

♂ • at 3 months of age, male mice fail to exhibit enhanced preference for the target quadrant and show increased latency to target counter in the Morris water maze test relative to wild-type males

decreased anxiety-related response ( J:220441 )

♀ • at 3 months of age, female mice show a significantly higher % of entries on open arms than wild-type females in the elevated plus maze test

♀ • in contrast, male mice show a normal % of entries on open arms relative to wild-type males

♀ • both sexes show a similar number of entries in closed arms relative to wild-type controls, suggesting normal overall locomotor activity

renal/urinary system

decreased urine osmolality ( J:220441 )

♂ • significant decrease in maximal urinary osmolality in male (but not female) mice after a 24 h water restriction relative to wild-type controls

increased urine flow rate ( J:220441 )

♂ • significant increase in mean urine volume in male mice under basal conditions with free access to drinking water relative to wild-type males

♂ • impaired ability to decrease urine flow in male (but not female) mice after a 24 h water restriction

homeostasis/metabolism

decreased urine osmolality ( J:220441 )

♂ • significant decrease in maximal urinary osmolality in male (but not female) mice after a 24 h water restriction relative to wild-type controls