Nlrp6^tm1Opaz
Targeted Allele Detail

Summary

• Symbol: Nlrp6^tm1Opaz
• Name: NLR family, pyrin domain containing 6; targeted mutation 1, Nelson Ruiz-Opazo
• MGI ID: MGI:5752293
• Synonyms: AVR/NAVR^-
• Gene: Nlrp6 Location: Chr7:140500815-140509105 bp, + strand Genetic Position: Chr7, 86.14 cM, cytoband F4
• Alliance: Nlrp6^tm1Opaz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220441
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An 800 bp region containing the 3' end of exon 4 plus part of the 5' end of intron 4 was replaced with a pgk-neo cassette via homologous recombination. RT-PCR analysis confirmed the absence of intact mRNA in kidneys from homozygous mutant mice. (J:220441)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp6 Mutation: 46 strains or lines available

References

• Original: J:220441 Herrera VL, et al., AVR/NAVR deficiency lowers blood pressure and differentially affects urinary concentrating ability, cognition, and anxiety-like behavior in male and female mice. Physiol Genomics. 2011 Jan 7;43(1):32-42
• All: 1 reference(s)