Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm4.1Shn mutation
(0 available);
any
Psen1 mutation
(46 available)
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mortality/aging
embryo
limbs/digits/tail
nervous system
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• thinning of the ventricular zone within the developing telencephalon at E16.5
• number of proliferating cells is reduced in the ventricular zone
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• thinning of the ventricular zone within the lateral ganglionic eminence at E16.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm2Shn mutation
(1 available);
any
Psen1 mutation
(46 available)
Psen1tm4.1Shn mutation
(0 available);
any
Psen1 mutation
(46 available)
Psen2tm1Haa mutation
(0 available);
any
Psen2 mutation
(31 available)
Tg(Camk2a-cre)1Shn mutation
(0 available)
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nervous system
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• in the neocortex and hippocampus
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• 31.5% reduction in cortical volume at 18 months of age
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• increase in apoptosis in the neocortex
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• 22.1% reduction in neuron number in the cerebral cortex at 18 months of age
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• mice exhibit age-dependent neurodegeneration throughout the cerebral cortex
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hematopoietic system
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• in the neocortex and hippocampus
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immune system
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• in the neocortex and hippocampus
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm4.1Shn mutation
(0 available);
any
Psen1 mutation
(46 available)
Psen2tm1Haa mutation
(0 available);
any
Psen2 mutation
(31 available)
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behavior/neurological
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• in the hidden-platform Morris water maze, mice exhibit higher latencies across the 14 day training period and show lower target quadrant occupancy in the probe test at day 7, indicating impaired reference memory acquisition
• although mice show similar target quadrant occupancies in the probe trial at da 13, they exhibit reduced target quadrant occupancy under partial-cue conditions in the probe trail at day 14, suggesting impaired hippocampal pattern completion
• in a spatial discrimination version of the radial arm maze task, mutants show more reference memory errors and a higher proportion of 45 degree turns into adjacent arms, indicating hippocampal spatial memory deficits
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nervous system
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• mice exhibit impaired short-term and long-term synaptic plasticity at hippocampal CA1 and CA3 synapses
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• long-term potentiation (LTP) at the Schaffer collateral-CA1 synapses induced by pairing presynaptic stimuli with postsynaptic depolarization is reduced
• LTP is impaired at commissural/associational (C/a)-CA3 synapses
• however, NMDAR-mediated EPSCs are unaffected
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• short-term depression during the initial phase of the LTP-inducing stimulus train is increased at (C/A)-CA3 synapses
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• mice show impaired short-term plasticity as indicated by reduced paired-pulse facilitation and frequency facilitation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm4.1Shn mutation
(0 available);
any
Psen1 mutation
(46 available)
Tg(PDGFB-APP)5Lms mutation
(1 available)
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nervous system
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• no amyloid plaque deposition is seen in the cerebral cortex even at 18 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm4.1Shn mutation
(0 available);
any
Psen1 mutation
(46 available)
Zbtb20Tg(PDGFB-APPSwInd)20Lms mutation
(1 available);
any
Zbtb20 mutation
(55 available)
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homeostasis/metabolism
nervous system
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• accelerated amyloid deposition in the cerebral cortex at 9 months of age compared to single Tg(PDGFB-APPSwInd)20Lms hemizygotes
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Analysis Tools