All Phenotypes Rr38<tm1.2Aafo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rr38^tm1.2Aafo
targeted mutation 1.2, Adolfo A Ferrando
MGI:5750934

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr38^tm1.2Aafo/Rr38^tm1.2Aafo	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6	MGI:5750943
ht2	Rr38^tm1.2Aafo/Rr38⁺	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6	MGI:5750944

Allelic Composition	Rr38^tm1.2Aafo/Rr38^tm1.2Aafo
Genetic Background	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:227747 )

N	• mice exhibit normal numbers of B cell precursors, myeloid progenitors, megakaryocytes and hematopoietic stem cells

small thymus ( J:227747 )

• at 6 weeks

decreased thymus weight ( J:227747 )

• at 6 weeks

thymus hypoplasia ( J:227747 )

• at 6 weeks

decreased thymocyte number ( J:227747 )

• at 6 weeks

increased DN3 thymocyte number ( J:227747 )

abnormal thymus physiology ( J:227747 )

• reduced thymocyte proliferation

• however, apoptosis levels are normal

decreased double-positive T cell number ( J:227747 )

decreased CD4-positive, alpha-beta T cell number ( J:227747 )

• in the spleen and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:227747 )

• in the spleen and lymph nodes

decreased single-positive T cell number ( J:227747 )

hematopoietic system

small thymus ( J:227747 )

• at 6 weeks

decreased thymus weight ( J:227747 )

• at 6 weeks

thymus hypoplasia ( J:227747 )

• at 6 weeks

decreased thymocyte number ( J:227747 )

• at 6 weeks

increased DN3 thymocyte number ( J:227747 )

abnormal thymus physiology ( J:227747 )

• reduced thymocyte proliferation

• however, apoptosis levels are normal

decreased double-positive T cell number ( J:227747 )

decreased CD4-positive, alpha-beta T cell number ( J:227747 )

• in the spleen and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:227747 )

• in the spleen and lymph nodes

decreased single-positive T cell number ( J:227747 )

endocrine/exocrine glands

small thymus ( J:227747 )

• at 6 weeks

decreased thymus weight ( J:227747 )

• at 6 weeks

thymus hypoplasia ( J:227747 )

• at 6 weeks

decreased thymocyte number ( J:227747 )

• at 6 weeks

increased DN3 thymocyte number ( J:227747 )

abnormal thymus physiology ( J:227747 )

• reduced thymocyte proliferation

• however, apoptosis levels are normal

Allelic Composition	Rr38^tm1.2Aafo/Rr38⁺
Genetic Background	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:227747 )

N	• thymus size is normal

decreased thymocyte number ( J:227747 )

• intermediate at 6 weeks

hematopoietic system

decreased thymocyte number ( J:227747 )

• intermediate at 6 weeks

endocrine/exocrine glands

decreased thymocyte number ( J:227747 )

• intermediate at 6 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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