Rr38^tm1.2Aafo
Targeted Allele Detail

Summary

• Symbol: Rr38^tm1.2Aafo
• Name: regulatory region 38; targeted mutation 1.2, Adolfo A Ferrando
• MGI ID: MGI:5750934
• Synonyms: N-Me^-
• Gene: Rr38 Location: Chr15:63127133-63128253 bp Genetic Position: Chr15, Syntenic
• Alliance: Rr38^tm1.2Aafo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227747
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: LoxP sites were inserted at positions 63,255,283 and 63,256,404 (GRCm38/mm10) flanking the mouse Notch Myc enhancer (N-Me) along with an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the enhancer sequence. (J:227747)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr38 Mutation: 0 strains or lines available

References

• Original: J:227747 Herranz D, et al., A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med. 2014 Oct;20(10):1130-7
• All: 1 reference(s)