Phenotypes associated with this allele

• Allele Symbol: Borcs6^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5750742
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Borcs6^tm1.1(KOMP)Vlcg/Borcs6^tm1.1(KOMP)Vlcg	B6N(Cg)-Borcs6^tm1.1(KOMP)Vlcg/J	MGI:6261992
ht2	Borcs6^tm1.1(KOMP)Vlcg/Borcs6^+	B6N(Cg)-Borcs6^tm1.1(KOMP)Vlcg/J	MGI:6261991

Genotype
MGI:6261992

hm1

• Allelic Composition: Borcs6^{tm1.1(KOMP)Vlcg}/Borcs6^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Borcs6^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 12882A-F6

Data Sources

IMPC Data for Borcs6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

failure to gastrulate ( J:279207 )

• no features typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder has formed at E6.5 but degenerates by E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 , J:279207 )

IMPC - JAX (J:211773)

MGI

• homozygous embryos are recovered at expected ratios at E7.5 but arrest prior to gastrulation (J:279207)

embryonic lethality, complete penetrance ( J:279207 )

• no homozygous embryos are recovered at E9.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6261991

ht2

• Allelic Composition: Borcs6^{tm1.1(KOMP)Vlcg}/Borcs6⁺
• Genetic Background: B6N(Cg)-Borcs6^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 12882A-F6

Data Sources

IMPC Data for Borcs6

adipose tissue

increased total body fat amount ( J:211773 )

♀

IMPC - JAX

homeostasis/metabolism

increased circulating calcium level ( J:211773 )

♀

IMPC - JAX