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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-en/Hoxb5,-EGFP)#Vchl
transgene insertion, Vincent Chi Hang Lui
MGI:5749814
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tg(CAG-Bgeo/ALPP)1Lbe/0
Tg(CAG-en/Hoxb5,-EGFP)#Vchl/0
Tg(Hoxb3-cre)1Pkht/0
involves: 129S1/Sv * 129X1/SvJ MGI:5749827
cn2
Tg(CAG-en/Hoxb5,-EGFP)#Vchl/0
Tg(Hoxb3-cre)1Pkht/0
Not Specified MGI:5749826


Genotype
MGI:5749827
cn1
Allelic
Composition
Tg(CAG-Bgeo/ALPP)1Lbe/0
Tg(CAG-en/Hoxb5,-EGFP)#Vchl/0
Tg(Hoxb3-cre)1Pkht/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Bgeo/ALPP)1Lbe mutation (1 available)
Tg(CAG-en/Hoxb5,-EGFP)#Vchl mutation (0 available)
Tg(Hoxb3-cre)1Pkht mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• retarded migration that either colonizes the proximal half of the small intestine or have just entered the small intestine

cellular
• retarded migration that either colonizes the proximal half of the small intestine or have just entered the small intestine




Genotype
MGI:5749826
cn2
Allelic
Composition
Tg(CAG-en/Hoxb5,-EGFP)#Vchl/0
Tg(Hoxb3-cre)1Pkht/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

digestive/alimentary system
• constricted in one mouse
• in one mouse
• due to food bolus in one mouse
• lacking ganglia in one mouse
• in one mouse
• due to food bolus in one mouse
• longer transit time

growth/size/body
• in one mouse

cellular
• defective migration into the small intestine
• however, neural crest cells are abundant in the stomach and no increase in apoptosis is detected

embryo
• defective migration into the small intestine
• however, neural crest cells are abundant in the stomach and no increase in apoptosis is detected

nervous system
• fewer numbers in the proximal and distal small intestines than in wild-type





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory