About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zwintem1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5749807
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zwintem1(IMPC)J/Zwintem1(IMPC)J C57BL/6NJ-Zwintem1(IMPC)J/J MGI:6263942
ht2
 		Zwintem1(IMPC)J/Zwint+ C57BL/6NJ-Zwintem1(IMPC)J/J MGI:6263941


Genotype
MGI:6263942
hm1
Allelic
Composition		 Zwintem1(IMPC)J/Zwintem1(IMPC)J
Genetic
Background		 C57BL/6NJ-Zwintem1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zwintem1(IMPC)J mutation (1 available); any Zwint mutation (19 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased inner cell mass proliferation ( J:279207 )
• inner cell mass (ICM) cells form a smaller than normal outgrowth colony after 3 days in culture
• however, blastocyst hatching occurs normally with apparent trophectoderm (TE) and primitive endoderm (PrE) cells
decreased embryonic epiblast cell proliferation ( J:279207 )
• epiblast cells form a smaller than normal outgrowth colony after 3 days in culture

embryo
decreased inner cell mass proliferation ( J:279207 )
• inner cell mass (ICM) cells form a smaller than normal outgrowth colony after 3 days in culture
• however, blastocyst hatching occurs normally with apparent trophectoderm (TE) and primitive endoderm (PrE) cells
decreased embryonic epiblast cell proliferation ( J:279207 )
• epiblast cells form a smaller than normal outgrowth colony after 3 days in culture

mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )
• normal looking blastocysts are present at higher than expected Mendelian ratios at E3.5 (36% versus 25%); no embryos are recovered at E7.5 with an excess number of resorption sites




Genotype
MGI:6263941
ht2
Allelic
Composition		 Zwintem1(IMPC)J/Zwint+
Genetic
Background		 C57BL/6NJ-Zwintem1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zwintem1(IMPC)J mutation (1 available); any Zwint mutation (19 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
hyperactivity ( J:211773 )
IMPC - JAX




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory