About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpr18tm1.1Cys
targeted mutation 1.1, Jason G Cyster
MGI:5708707
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpr18tm1.1Cys/Gpr18tm1.1Cys involves: C57BL/6 MGI:5750103


Genotype
MGI:5750103
hm1
Allelic
Composition		 Gpr18tm1.1Cys/Gpr18tm1.1Cys
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr18tm1.1Cys mutation (0 available); any Gpr18 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:219661 )
N
• normal numbers of alpha/beta and gamma/delta T cells and B cells
• lymphocyte development in thymus and bone marrow is normal
decreased CD8-positive, alpha-beta T cell number ( J:219661 )
• deficiencies in CD8alphaalpha and CD8alphabeta alpha-beta T cells
decreased CD8-positive, gamma-delta intraepithelial T cell number ( J:219661 )
• intestinal intraepithelial lymphocytes are deficient in CD8alphaalpha gamma-delta T cells

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:219661 )
• deficiencies in CD8alphaalpha and CD8alphabeta alpha-beta T cells
decreased CD8-positive, gamma-delta intraepithelial T cell number ( J:219661 )
• intestinal intraepithelial lymphocytes are deficient in CD8alphaalpha gamma-delta T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory