Phenotypes associated with this allele

• Allele Symbol: Fgfrl1^tm2.1True
• Allele Name: targeted mutation 2.1, Beat Trueb
• Allele ID: MGI:5707709
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfrl1^tm2.1True/Fgfrl1^tm2.1True	B6.Cg-Fgfrl1^tm2.1True	MGI:5762557
ht2	Fgfrl1^tm2.1True/Fgfrl1^+	B6.Cg-Fgfrl1^tm2.1True	MGI:5762558
ht3	Fgfrl1^tm1True/Fgfrl1^tm2.1True	B6.Cg-Fgfrl1^tm1True Fgfrl1^tm2.1True	MGI:5762560

Genotype
MGI:5762557

hm1

• Allelic Composition: Fgfrl1^tm2.1True/Fgfrl1^tm2.1True
• Genetic Background: B6.Cg-Fgfrl1^tm2.1True

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Morphology of kidneys in heterozygous and homozygous Fgfrl1^tm2.1True mice

renal/urinary system

decreased renal glomerulus number ( J:218981 )

• at E17.5, homozygotes display a slight but significant reduction in the total number of glomeruli relative to wild-type controls

mortality/aging

mortality/aging ( J:218981 )

N • surprisingly, homozygotes are viable and do not exhibit any overt malformations

N • one male homozygote survived for >18 months with no apparent pathology

muscle

muscle phenotype ( J:218981 )

N • surprisingly, diaphragm morphology is normal at E18.5, as shown by H&E staining

skeleton

skeleton phenotype ( J:218981 )

N • surprisingly, the skull and long bones appear morphologically normal at E18.5, as shown by alcian/alizarin staining

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:218981 )

N • contrary to expectation, production of insulin by pancreatic beta-cells is normal at E18.5

N • no signs of hyperglycemia are observed

Genotype
MGI:5762558

ht2

• Allelic Composition: Fgfrl1^tm2.1True/Fgfrl1⁺
• Genetic Background: B6.Cg-Fgfrl1^tm2.1True

Morphology of kidneys in heterozygous and homozygous Fgfrl1^tm2.1True mice

renal/urinary system

decreased renal glomerulus number ( J:218981 )

• at E17.5, heterozygotes display a slight but significant reduction in the total number of glomeruli relative to wild-type controls

• however, both survival and overall phenotype remain normal

Genotype
MGI:5762560

ht3

• Allelic Composition: Fgfrl1^tm1True/Fgfrl1^tm2.1True
• Genetic Background: B6.Cg-Fgfrl1^tm1True Fgfrl1^tm2.1True

normal phenotype

no abnormal phenotype detected ( J:218981 )

• mice are viable, fertile and phenotypically normal; one male survived for >21 months