Analysis Tools
mortality/aging
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• however, the phenotype is rescued in mice crossing to a line expressing the human gene
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hematopoietic system
| N |
• myeloid populations are normal
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• with loss of patchy appearance
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• 20% of wild-type in moribund mice
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• starting at P10 with massive degeneration and loss of organ architecture
• however, the phenotype is rescued in mice crossing to a line expressing the human gene
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• slightly in the thymus
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• in the thymus
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• slightly in the blood
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• four-fold in the thymus
• two-fold in the spleen
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• four-fold in the thymus
• two-fold in the spleen
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• profound in the blood
• however, the phenotype is rescued in mice crossing to a line expressing the human gene
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• in the thymus
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• in the spleen
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• starting at P10 with massive degeneration
• however, the phenotype is rescued in mice crossing to a line expressing the human gene
|
behavior/neurological
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• in hindlimbs as early as P10
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• as early as P10
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spasticity
(
J:221543
)
nervous system
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• arising from either mitochondria or endoplasmic reticulum in the cell bodies of motor neurons mainly in the medulla
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• vacuoles arising from either mitochondria or endoplasmic reticulum are detected in the cell bodies of motor neurons mainly in the medulla
• abnormal mitochondria in the bodies of motor neurons but not the dendrites or synapses
• however, nuclei and nucleoli are normal
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growth/size/body
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• however, the phenotype is rescued in mice crossing to a line expressing the human gene
|
cellular
endocrine/exocrine glands
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• with loss of patchy appearance
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• 20% of wild-type in moribund mice
|
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• starting at P10 with massive degeneration and loss of organ architecture
• however, the phenotype is rescued in mice crossing to a line expressing the human gene
|
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• in the thymus
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immune system
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• with loss of patchy appearance
|
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• 20% of wild-type in moribund mice
|
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• starting at P10 with massive degeneration and loss of organ architecture
• however, the phenotype is rescued in mice crossing to a line expressing the human gene
|
|
• slightly in the thymus
|
|
• in the thymus
|
|
• four-fold in the thymus
• two-fold in the spleen
|
|
• four-fold in the thymus
• two-fold in the spleen
|
|
• profound in the blood
• however, the phenotype is rescued in mice crossing to a line expressing the human gene
|
|
• in the thymus
|
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• in the spleen
|
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• starting at P10 with massive degeneration
• however, the phenotype is rescued in mice crossing to a line expressing the human gene
|
muscle
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• starting at the hindlimb and progressing to the forelimbs
• however, the phenotype is rescued in mice crossing to a line expressing the human gene
|
