Phenotypes associated with this allele

• Allele Symbol: Trpm7^tm1.1Mkma
• Allele Name: targeted mutation 1.1, Masayuki Matsushita
• Allele ID: MGI:5707246
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpm7^tm1.1Mkma/Trpm7^tm1.1Mkma	B6.129-Trpm7^tm1.1Mkma	MGI:5770796

Genotype
MGI:5770796

hm1

• Allelic Composition: Trpm7^tm1.1Mkma/Trpm7^tm1.1Mkma
• Genetic Background: B6.129-Trpm7^tm1.1Mkma

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:221252 )

• kinase-inactive homozygotes are viable and develop normally with no significant differences in body weight, food intake, general locomotor activity or serum total Mg²⁺ and Ca²⁺ levels relative to wild-type controls

• although basal native channel activity is significantly increased prior to cytoplasmic Mg²⁺ depletion, maximal current density measured after Mg²⁺ depletion is not significantly altered in peritoneal macrophages, indicating normal native channel function