Phenotypes associated with this allele

• Allele Symbol: Dusp5^tm1.1Achn
• Allele Name: targeted mutation 1.1, Andrew C Chan
• Allele ID: MGI:5706941
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dusp5^tm1.1Achn/Dusp5^tm1.1Achn	involves: C57BL/6NCrl	MGI:5906763
cx2	Dusp5^tm1.1Achn/Dusp5^tm1.1Achn Rag2^tm1.1Cgn/Rag2^tm1.1Cgn	involves: C57BL/6NCrl	MGI:5906764

Genotype
MGI:5906763

hm1

• Allelic Composition: Dusp5^tm1.1Achn/Dusp5^tm1.1Achn
• Genetic Background: involves: C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:218203 )

N • mice exhibit a normal number of CD4+ and CD8+ T cells in spleen and lymph nodes

increased T cell proliferation ( J:218203 )

• of CD62L^hi CD4+ T cells activated with anti-CD3 and anti-CD28 antibodies

• however, effector/memory CD62L^low CD4+ T cell proliferation is normal

increased thymocyte number ( J:218203 )

• modest increase in Cd4+ and CD8+ thymocytes

abnormal susceptibility to parasitic infection ( J:218203 )

• following N. brasiliensis infection, mice exhibit lower worm burden and increased circulating and bronchoalveolar lavage fluid eosinophils compared with control mice

endocrine/exocrine glands

increased thymocyte number ( J:218203 )

• modest increase in Cd4+ and CD8+ thymocytes

hematopoietic system

increased T cell proliferation ( J:218203 )

• of CD62L^hi CD4+ T cells activated with anti-CD3 and anti-CD28 antibodies

• however, effector/memory CD62L^low CD4+ T cell proliferation is normal

increased thymocyte number ( J:218203 )

• modest increase in Cd4+ and CD8+ thymocytes

cellular

increased T cell proliferation ( J:218203 )

• of CD62L^hi CD4+ T cells activated with anti-CD3 and anti-CD28 antibodies

• however, effector/memory CD62L^low CD4+ T cell proliferation is normal

Genotype
MGI:5906764

cx2

• Allelic Composition: Dusp5^tm1.1Achn/Dusp5^tm1.1Achn; Rag2^tm1.1Cgn/Rag2^tm1.1Cgn
• Genetic Background: involves: C57BL/6NCrl

immune system

increased eosinophil cell number ( J:218203 )

• circulating at 6 and 13 following N. brasiliensis infection

• in the blood, bronchoalveolar lavage fluid, spleen and bone marrow at 14 days following N. brasiliensis infection

abnormal eosinophil physiology ( J:218203 )

• following N. brasiliensis infection, eosiniphils exhibit a cell intrinsic 2- to 3-fold increased proliferation and decreased apoptosis compared with cells from control mice

abnormal susceptibility to parasitic infection ( J:218203 )

• following N. brasiliensis infection, mice exhibit increased circulating eosinophils at 6 and 13 days compared with control mice

• following N. brasiliensis infection, mice exhibit an increased in eosinophils in the blood, bronchoalveolar lavage fluid, spleen and bone marrow at 14 days compared with control mice

• following N. brasiliensis infection, mice exhibit lower worm burden compared with control mice

• treatment with antibodies to deplete NK cells does not alter phenotype

hematopoietic system

increased eosinophil cell number ( J:218203 )

• circulating at 6 and 13 following N. brasiliensis infection

• in the blood, bronchoalveolar lavage fluid, spleen and bone marrow at 14 days following N. brasiliensis infection

abnormal eosinophil physiology ( J:218203 )

• following N. brasiliensis infection, eosiniphils exhibit a cell intrinsic 2- to 3-fold increased proliferation and decreased apoptosis compared with cells from control mice