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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccdc80tm1Ppal
targeted mutation 1, Pierlorenzo Pallante
MGI:5706809
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccdc80tm1Ppal/Ccdc80tm1Ppal Not Specified MGI:5790811
ht2
 		Ccdc80tm1Ppal/Ccdc80+ Not Specified MGI:5790812


Genotype
MGI:5790811
hm1
Allelic
Composition		 Ccdc80tm1Ppal/Ccdc80tm1Ppal
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc80tm1Ppal mutation (0 available); any Ccdc80 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased ovarian carcinoma incidence ( J:217742 )
• 4 of 20 (20%) of homozygotes developed ovarian carcinomas, one of them showing liver metastasis
increased thyroid adenoma incidence ( J:217742 )
• 6 of 20 (30%) of homozygotes developed thyroid adenomas
• thyroid adenomas and ovarian carcinomas were never present in the same mouse
increased metastatic potential ( J:217742 )
• 1 of 4 ovarian carcinomas showed the presence of liver metastasis

cellular
decreased fibroblast apoptosis ( J:217742 )
• after 72 hrs of serum starvation, the % of apoptotic MEFs (sub-G1 cell population) was lower than that in wild-type MEFs
• after treatment with 500 nM doxorubicin for 16 hrs, the % of TUNEL-positive MEFs was significantly lower than that in wild-type MEFs
increased fibroblast proliferation ( J:217742 )
• mouse embryonic fibroblasts (MEFs) derived from E12.5 embryos showed a significantly higher proliferation rate than wild-type MEFs

endocrine/exocrine glands
increased ovarian carcinoma incidence ( J:217742 )
• 4 of 20 (20%) of homozygotes developed ovarian carcinomas, one of them showing liver metastasis
increased thyroid adenoma incidence ( J:217742 )
• 6 of 20 (30%) of homozygotes developed thyroid adenomas
• thyroid adenomas and ovarian carcinomas were never present in the same mouse

reproductive system
increased ovarian carcinoma incidence ( J:217742 )
• 4 of 20 (20%) of homozygotes developed ovarian carcinomas, one of them showing liver metastasis




Genotype
MGI:5790812
ht2
Allelic
Composition		 Ccdc80tm1Ppal/Ccdc80+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc80tm1Ppal mutation (0 available); any Ccdc80 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased fibroblast proliferation ( J:217742 )
• MEFs derived from E12.5 embryos showed an intermediate increase in their proliferation rate compared with wild-type and homozygous mutant MEFs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory